اثر یک دوره تمرین هوازی بر شاخص‌های عملکرد اندوتلیالی زنان یائسه مبتلا به پرفشار خونی

    Background & Aims : Aging and the loss of endogenous estrogen production after menopause are accompanied by increases in blood pressure and endothelial dysfunction. Exercise training improves endothelial function in patients with hypertension. The aim of this study was to examine the effect of aerobic training on some markers of endothelial function in hypertensive postmenopausal women.   Materials & Methods: This quasi-experimental research was performed on 20 sedentary hypertensive postmenopausal women whom were selected according to purposive and availabile sampling , and were randomly divided into aerobic exercise(10 person) and control groups(10 person). Training program consisted of 45-60 minute rhytmic aerobic exercise at 40-60 percent of maximal heart rate, 3 sessions per week for 6 weeks. Blood samples were taken before and after 6 weeks. Samples were analyzed for measure the intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels.   Result: After 6 weeks aerobic training, intercellular adhesion molecule-1 levels significantly reduced in aerobic exercise group(p=0. 001). But no significant reductions were found in vascular cell adhesion molecule-1 and E-selectin in trained women compared to the control group . In addition chronic exercise training was accompanied by a significant decrease in systolic and diastolic blood pressure in aerobic exercise group (p=0. 001, p=0. 015, respectively).   Conclusion: Exercise training might be considered as an effective non-pharmacological intervention for attenuating hypertention and mitigate intercellular adhesion molecule-1 in hypertensive postmenopausal women.   SOURCE: URMIA MED J 2013: 24(8): 632 ISSN: 1027-3727